Microchimerism of maternal origin persists into adult life
نویسندگان
چکیده
منابع مشابه
Microchimerism of maternal origin persists into adult life.
Recent studies indicate that fetal cells persist in maternal blood for decades after pregnancy. Maternal cells are known to engraft and persist in infants with immunodeficiency, but whether maternal cells persist long-term in immunocompetent offspring has not specifically been investigated. We developed sensitive human leukocyte antigen-specific (HLA-specific) PCR assays and targeted nonshared ...
متن کاملMicrochimerism and Renal Transplantation: Doubt Still Persists
Background: The Presence of donor leukocytes in recipients of organ allograft has been shown even several years after transplantation. However, it remains unclear whether this donor cell microchimerism plays an effective role in allograft acceptance or is simply a consequence of immunosuppressive conditions in recipients. Objective: To study microchimerism in a group of kidney transplant recipi...
متن کاملMicrochimerism and renal transplantation: doubt still persists.
OBJECTIVE We sought to study microchimerism in a group of kidney transplant recipients. MATERIALS AND METHODS In this study, the peripheral blood microchimerism (PBM) after renal transplantation was retrospectively evaluated in 32 male-to-female recipients of living unrelated or cadaveric donor renal transplants. Using a nested polymerase chain reaction (PCR) amplification specific for SRY re...
متن کاملmicrochimerism and renal transplantation: doubt still persists
background: the presence of donor leukocytes in recipients of organ allograft has been shown even several years after transplantation. however, it remains unclear whether this donor cell microchimerism plays an effective role in allograft acceptance or is simply a consequence of immunosuppressive conditions in recipients. objective: to study microchimerism in a group of kidney transplant recipi...
متن کاملPregnancy, Microchimerism, and the Maternal Grandmother
BACKGROUND A WOMAN OF REPRODUCTIVE AGE OFTEN HARBORS A SMALL NUMBER OF FOREIGN CELLS, REFERRED TO AS MICROCHIMERISM: a preexisting population of cells acquired during fetal life from her own mother, and newly acquired populations from her pregnancies. An intriguing question is whether the population of cells from her own mother can influence either maternal health during pregnancy and/or the ne...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1999
ISSN: 0021-9738
DOI: 10.1172/jci6611